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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ITK
All Species:
31.52
Human Site:
S539
Identified Species:
69.33
UniProt:
Q08881
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q08881
NP_005537.3
620
71831
S539
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
Chimpanzee
Pan troglodytes
XP_001136073
620
71772
S539
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
Rhesus Macaque
Macaca mulatta
XP_001113468
620
71884
S539
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
Dog
Lupus familis
XP_546277
710
81746
V627
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
Q03526
625
72273
S544
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
Rat
Rattus norvegicus
Q07014
512
58642
E435
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507397
745
86729
S664
F
N
R
Y
S
S
K
S
D
V
W
S
F
G
V
Chicken
Gallus gallus
Q8JH64
657
75860
S576
Y
S
K
F
S
S
K
S
D
V
W
S
F
G
V
Frog
Xenopus laevis
P10936
537
60339
L459
F
G
I
L
L
T
E
L
V
A
K
G
R
V
P
Zebra Danio
Brachydanio rerio
NP_571179
616
71601
S536
F
G
K
Y
S
S
K
S
D
V
W
S
F
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08630
786
87374
S704
Y
T
R
F
S
S
K
S
D
V
W
A
Y
G
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
80.5
N.A.
93.4
32.2
N.A.
72.8
50.3
32.2
58.7
N.A.
37.4
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
99.5
83.2
N.A.
95.8
50.3
N.A.
77.9
68.3
50.3
74.3
N.A.
53.1
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
100
6.6
N.A.
93.3
80
6.6
86.6
N.A.
66.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
100
13.3
N.A.
100
100
20
93.3
N.A.
100
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
0
0
0
10
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
73
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
19
10
0
0
0
0
0
0
0
% E
% Phe:
64
10
0
19
0
0
0
0
10
0
10
0
64
0
0
% F
% Gly:
0
19
10
0
0
0
0
0
0
0
0
10
10
73
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
10
0
0
0
0
10
0
0
0
0
0
10
% I
% Lys:
0
10
19
0
0
0
73
0
0
0
10
0
0
10
0
% K
% Leu:
0
0
0
10
19
10
0
10
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
55
0
0
0
0
0
0
0
0
0
19
0
0
% R
% Ser:
10
46
0
0
82
73
0
73
0
10
0
73
0
0
10
% S
% Thr:
0
10
0
0
0
10
0
0
0
0
10
0
0
0
0
% T
% Val:
10
0
0
0
0
0
0
10
10
82
0
0
0
10
73
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
73
0
0
0
0
% W
% Tyr:
19
0
0
55
0
0
10
0
0
0
0
10
10
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _